Process for producing aldol derivative using fluorinated ketene silyl acetal

摘要

PROBLEM TO BE SOLVED: To provide a method for simply and effectively producing a derivative of aldol having a perfluoroalkyl group, a polyfluoroalkyl group or a fluoroalkyl group.;SOLUTION: The invention relates to the method for production of derivatives of aldol represented by the formula R²¹(R¹²R¹³R¹⁴SiO)CH-C(R_f)(OSiR¹⁵R¹⁶R¹⁷)-CO₂R¹¹ or R³¹(R³²O)CH-C(R_f)(OSiR¹⁵R¹⁶R¹⁷)-CO₂R¹¹comprising reaction of a ketene silyl acetal compound expressed by R_f(R¹²R¹³R¹⁴SiO)C=C(OSiR¹⁵R¹⁶R¹⁷)(OR¹¹) with a R²¹CHO compound or a R³¹CH(OR³²)(OR³³) compound in the presence of a Lewis acid, (In the formula R_f represents a perfluoroalkyl group, a polyfluoroalkyl group or a fluoroalkyl group, R¹¹ represents H or a monovalent organic group, and R²¹ represents a (substituted) cyclic or acyclic hydrocarbon group, R³¹, R³² and R³³ are each a (substituted) cyclic or acyclic hydrocarbons.).;COPYRIGHT: (C)2006,JPO&NCIPI