AGENT FOR REGULATING, INHIBITING, OR MODULATING ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AS UNIQUE MEANS TO BOTH LOWER INTRAOCULAR PRESSURE AND TREAT GLAUCOMATOUS RETINOPATHY/OPTIC NEUROPATHY

摘要

PPROBLEM TO BE SOLVED: To reduce IOP (intraocular pressure) and/or to provide neuroprotection to optic disk and/or retinal ganglion cells through a pathogenic pathway. PSOLUTION: A method for reducing IOP and providing neuroprotection to a patient in need, who needs the neuroprotection through IOP reduction, by administering a therapeutically effective amount of at least one non-nucleotide agent or non-protein agent that inhibits expression and/or signal transmission of connective tissue growth factor (CTGF) is provided. A method for reducing IOP of a patient requiring IOP reduction is also provided, including a step of administering the therapeutically effective amount of a composition comprising at least one non-nucleotide agent or non-protein agent that inhibits expression, signal transmission or biological function of CTGF, and a pharmaceutically acceptable carrier. PCOPYRIGHT: (C)2011,JPO&INPIT