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Novel Plexin polypeptide, DNA encoding the same, and use thereof
Novel Plexin polypeptide, DNA encoding the same, and use thereof
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机译:新的丛蛋白多肽,编码该多肽的DNA及其用途
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摘要
The object of the invention is to provide novel DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide, or an antibody against the polypeptide, which is useful for development and screening of prophylactic, therapeutic and diagnostic drug for angiogenesis and conservation of functions in various organs, angiogenesis at the time of tumor and regeneration of various organs, proliferation, differentiation and preservation of function of the cells in various organs, aging, and dysfunction. Means to solve the problem A DNA comprising a base sequence encoding one of the following polypeptide (a) or (b): (a) a polypeptide comprising the full length or a part of an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:15 or SEQ ID NO:18, and (b) a polypeptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:15 or SEQ ID NO:18 by deletion, substitution or addition of a part of the amino acids and having a biological activity substantially equivalent to the polypeptide (a).
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机译:本发明的目的是提供新的DNA,包含该DNA的基因,由该DNA编码的新的多肽,包含该多肽的重组蛋白或针对该多肽的抗体,其可用于开发和筛选预防,治疗和预防疾病。诊断药物,用于各种器官的血管生成和功能的维持,肿瘤发生时的血管生成和各种器官的再生,各种器官的细胞功能的增殖,分化和保存,衰老和功能障碍。解决该问题的手段一种包含编码以下多肽(a)或(b)之一的碱基序列的DNA:(a)包含相同或基本相同的氨基酸序列的全长或一部分的多肽(b)多肽,其包含衍生自SEQ ID NO:1,SEQ ID NO:15或SEQ ID NO:18表示的氨基酸序列的氨基酸序列, SEQ ID NO:15或SEQ ID NO:18是通过缺失,取代或添加一部分氨基酸并具有与多肽(a)基本相同的生物学活性而形成的。
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