As the useful intermediate for the anti-bacterial quinolone glaze, the alkyl 3 cyclobutylpropylamino 2 the 2,4 dibromo 3 (jihuruorometokishi) the benzoyl one pot synthesis method of 2 puropenoeto

摘要

The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates in which R represents methyl or ethyl, which are valuable intermediates for the production of highly active antibacterial quinolone medicaments.