METHOD FOR EVALUATING CARCINOGENIC TOXICITY, AND AGENT FOR PREVENTING AND TREATING CARCINOGENESIS

摘要

PROBLEM TO BE SOLVED: To provide an inhibitor of the dimerization of a protein having tyrosine kinase activities, and to provide a method for screening a carcinogenesis inhibitor.;SOLUTION: There is provided the inhibitor of the dimerization of the protein having the tyrosine kinase activities, using a thiol compound as an active ingredient. The thiol compound is one or more kinds selected from cysteine, N-acetylcysteine (NAC) and cysteine derivatives having thiol groups. The method for screening the carcinogenesis inhibitor includes a step for feeding one or more kinds of specimens to an evaluation system containing the protein having the tyrosine kinase activities, and a step for evaluating carcinogenesis-inhibiting abilities by measuring the amount of the dimer of the protein and/or the tyrosine kinase activities.;COPYRIGHT: (C)2011,JPO&INPIT