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Analogues of analgesic peptides derived from South American rattlesnake venom, their use, compositions, methods of preparation and purification

机译:南美响尾蛇毒的镇痛肽类似物,其用途,组成,制备和纯化方法

摘要

The present invention refers to analog compounds of peptides having the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, including analgesic peptides derived from snakes of species such as Crotalus durissus terrificus; their uses in the treatment, diagnosis and prevention of painful conditions or mediated by opioid receptors, their pharmaceutical compositions and their methods of preparation and purification, including their uses in the identification of analgesic compounds.
机译:本发明涉及具有氨基酸序列SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:3或SEQ ID NO:4的肽的类似物化合物,包括衍生自诸如Crotarus durissus的蛇类的止痛肽。很棒它们在治疗,诊断和预防疼痛状况或由阿片受体介导的疼痛中的用途,其药物组合物及其制备和纯化方法,包括其在鉴定镇痛剂中的用途。

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