Method for producing valsartan salt effective for producing valsartan

摘要

The invention relates to a new salt of Valsartan, in particular to the high-purity dilithium salt of Valsartan, its polymorphs and solvates or hydrates thereof, useful for obtaining Valsartan with a high yield. The process for obtaining the dilithium salt of Valsartan ( I ) comprises i) Coupling of the intermediate ( II ) with the 2-(1 H -tetrazole-5-il)-phenylboronic acid of formula ( III ), wherein said coupling takes place in the presence of a lithium base, and a mixture of water and water-miscible organic solvent and a palladium catalyst, to give the dilithium salt of Valsartan of formula ( I ).