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Bora Bruno manufacturing method of phosphate monomer and oligonucleotide derivatives using the same
Bora Bruno manufacturing method of phosphate monomer and oligonucleotide derivatives using the same
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机译:宝来布鲁诺制造磷酸酯单体和寡核苷酸衍生物的方法
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摘要
The present invention has an object to provide a useful anti-sense molecule, such as boranophosphate oligomers capable of withstanding practical use, boranophosphate monomer represented by the following formula (1), and the strength given to using the same by condensation reaction in the presence of a condensing agent and a base to solve the above problems. Wherein pyrimidine base or purine base, represents a derivative thereof, or a dimethoxytrityl group,, R 1 is a monomethoxytrityl group, and R 2, a hydrogen atom, an alkoxy group, B 1 is alkenyl oxy group, an acyloxy group, I represent a trialkylsilyl group. ]
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