$$$-PHOSPHATE,N,P-NONPROTECTED PHOSPHOTHIOATE OLIGODEOXYNUCLEOTIDES AS PARENTAL COMPOUNDS FOR SYNTHESIS OF PHOSPHOTHIOATE OLIGONUCLEOTIDE REAGENTS FOR BIOTECHNOLOGICAL PROCESSES, PHOSPHOTHIOATE OLIGONUCLEOTIDE DERIVATIVES CONTAINING 3'- AND/OR 5'-BOUND CHEMICAL GROUPS AS PHOSPHOTHIOATE OLIGONUCLEOTIDE REAGENTS FOR BIOTECHNOLOGICAL PROCESSES AND METHOD OF THEIR SYNTHESIS

摘要

FIELD: organic chemistry, biotechnology. SUBSTANCE: product: $$$-phosphate,N,P-nonprotected phosphothioate oligodeoxynucleotides (I) $$$, phosphothioate oligonucleotide derivatives (II) and method of synthesis of (II) by interaction of $$$- or $$$-phosphate,N,P-nonprotected phosphothioate oligodeoxynucleotides with corresponding azoles or aminopyridines or aliphatic amine derivatives in the presence of triphenylphosphanedipyridyldisulfide and N-methylimidazole as catalyst. EFFECT: improved method of synthesis. 1 tbl