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Method for analyzing sulfated polysaccharide or sulfated oligosaccharide, pharmaceutical composition containing sulfated polysaccharide or sulfated oligosaccharide, and method for producing medicament
Method for analyzing sulfated polysaccharide or sulfated oligosaccharide, pharmaceutical composition containing sulfated polysaccharide or sulfated oligosaccharide, and method for producing medicament
It is intended to provide: an analytical method whereby the structure of a sulfated polysaccharide or a sulfated oligosaccharide can be highly sensitively analyzed; a pharmaceutical composition and a drug containing a sulfated polysaccharide or a sulfated oligosaccharide having an excellent biological activity; a method of producing a pharmaceutical composition and a drug containing a sulfated polysaccharide or a sulfated oligosaccharide; and a method of treating, diagnosing, symptom-relieving and preventing a disease. A sulfated polysaccharide or a sulfated oligosaccharide is enzymatically digested and the obtained product containing a monosaccharide, a disaccharide or a trisaccharide is analyzed by mass spectrometry. Thus, the structure of the sulfated polysaccharide or the sulfated oligosaccharide is analyzed and its qualities such as a biological activity are evaluated, which makes it possible to produce an excellent pharmaceutical composition or drug. The above-described pharmaceutical composition and drug have excellent biological activities, that have been found hereby, relating to the tumor metastasis inhibitory activity, dengue virus-infection inhibitory activity, growth factor-binding activity and so on of chondroitin sulfate.
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