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Mutations in NOD2 are associated with fibrotic stenosis disease in patients with Crohn's disease
Mutations in NOD2 are associated with fibrotic stenosis disease in patients with Crohn's disease
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机译:克罗恩病患者中NOD2突变与纤维化性狭窄症有关
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摘要
The present invention is a method for predicting the susceptibility thereto or diagnosing clinical subtypes of Crohn's disease characterized by fibrotic stenosis disease, in an individual, the method is linked to NOD2 / CARD15 locus It is from the step of determining the presence or absence of fibrotic stenosis predisposing allele was, here, the presence of a fibrotic stenosis predisposing allele, diagnosis of clinical subtypes of Crohn's disease, which is characterized by fibrotic stricture disease or I to provide predictive of susceptibility to it, and how. In the method of the present invention, for example, a clinical subtype of Crohn's disease such, may be characterized by fibrotic stenosis disease that is independent of the small intestine affected.
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