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MODIFICATION OF HYDROGENASE ACTIVITIES IN THERMOPHILIC BACTERIA TO ENHANCE ETHANOL PRODUCTION

机译：改变嗜热细菌中的加氢酶活性以增强乙醇的生产

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摘要

Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced hydrogenase activities. One such mutant strain with both the ldh and hydtrA genes inactivated shows a significant increase in ethanol production. Manipulation of hydrogenase activities provides a new approach for enhancing substrate utilization and ethanol production by biomass-fermenting microorganisms.

机译：细菌消耗各种生物质衍生的底物并产生乙醇。氢化酶基因已在糖热厌氧杆菌中失活，以产生具有降低的氢化酶活性的突变菌株。 Ldh和hydtrA基因都被灭活的此类突变株显示出乙醇产量的显着增加。氢化酶活性的操纵提供了一种新的途径，可以提高生物质发酵微生物的底物利用率和乙醇产量。 展开▼

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公开/公告号US2011256601A1

专利类型

公开/公告日2011-10-20

原文格式PDF

申请/专利权人 ARTHUR JOSEPHUS SHAW IV;LEE LYND;DAVID A. HOGSETT;
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申请/专利号US20080808764

发明设计人 ARTHUR JOSEPHUS SHAW IV;LEE LYND;DAVID A. HOGSETT;
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申请日2008-12-17

分类号C12P7/10;C12N1/19;C12N9/02;C12P7/06;C12N1/20;C07H21/04;C12N1/21;C12N15/63;

国家 US

入库时间 2022-08-21 18:16:33

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3. MODIFICATION OF HYDROGENASE ACTIVITIES IN THERMOPHILIC BACTERIA TO ENHANCE ETHANOL PRODUCTION [P] . 欧洲知识产权局专利： EP2235168A1 . 2010-10-06

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