首页> 外国专利> Analogues Of 1,3-Bis(4-Nitrophenyl)Triazenes, Their Pharmaceutically Acceptable Salts And N-Acyl Derivatives For Tumour Treatment

Analogues Of 1,3-Bis(4-Nitrophenyl)Triazenes, Their Pharmaceutically Acceptable Salts And N-Acyl Derivatives For Tumour Treatment

机译:1,3-双(4-硝基苯基)三氮烯,其可药用盐和N-酰基衍生物的类似物用于肿瘤治疗

摘要

The present invention refers to analogues of 1,3-bis(4-nitrophenyl)triazenes, their pharmaceutically acceptable salts and N-acyl derivatives for the treatment of different types of tumours. Said compounds show cytotoxicity at very low concentrations (IC50 0.22 to 12.8 μM), and good solubility. These compounds can be used in the treatment of tumour patients as single drugs or in combination with other cytostatics.
机译:本发明涉及用于治疗不同类型的肿瘤的1,3-双(4-硝基苯基)三氮烯的类似物,其药学上可接受的盐和N-酰基衍生物。所述化合物在非常低的浓度(IC 50 0.22至12.8μM)下显示出细胞毒性,并具有良好的溶解性。这些化合物可作为单一药物或与其他细胞抑制剂联合用于治疗肿瘤患者。

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