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COMPLEXES OF GRP94 WITH HUMAN IMMUNOGLOBULIN G
COMPLEXES OF GRP94 WITH HUMAN IMMUNOGLOBULIN G
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机译:GRP94与人免疫球蛋白G的复合物
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摘要
Complexes are described that form in vitro following incubation of “Heat Shock Protein” (HSP) “Glucose-regulated Protein” 94 (Grp94) with human non-immune immunoglobulin G. Results show that complexes of Grp94-IgG are resistant to denaturing agents. Moreover, complexes display an important cytokine-like property that can be exploited to induce positive effects of immuno-modulation in pathologies characterized by either a reduced or exacerbated immune response. In addition, stability of Grp94-IgG complexes make them useful as diagnostic tools to detect antibodies directed against Grp94 in various pathological conditions.
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