GRP94 COMPLEXES WITH HUMAN G IMMUNOGLOBULIN

摘要

Complexes are described that form in vitro following incubation of Heat Shock Protein (HSP) Glucose-regulated Protein 94 (Grp94) with human non-immune immunoglobulin G. Results show that complexes of Grp94-IgG are resistant to denaturing agents. Moreover, complexes display an important cytokine-like property that can be exploited to induce positive effects of immuno-modulation in pathologies characterized by either a reduced or exacerbated immune response. In addition, stability of Grp94-IgG complexes make them useful as diagnostic tools to detect antibodies directed against Grp94 in various pathological conditions.