首页>
外国专利>
METHODS AND KITS FOR SUSTAINING eNOS ACTIVITY TO INHIBIT PLATELET AGGREGATION, AND CLOT RETRACTION, AND PROMOTE FIBRINOLYSIS
METHODS AND KITS FOR SUSTAINING eNOS ACTIVITY TO INHIBIT PLATELET AGGREGATION, AND CLOT RETRACTION, AND PROMOTE FIBRINOLYSIS
展开▼
机译:维持eNOS抑制血小板凝集和凝块退缩并促进纤维蛋白溶解的活性的方法和试剂盒
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain.
展开▼