首页> 外国专利> Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor

Polarization-enhanced detector with gold nanorods for detecting nanoscale rotational motion and method therefor

机译:用于检测纳米级旋转运动的带有金纳米棒的偏振增强检测器及其方法

摘要

A nanoscale motion detector attaches a gold nanorod (30) to the rotating arm (26) of a molecular structure (10) to cause the nanoparticle to rotate. The molecular structure is an F1-ATPase enzyme. The gold nanorod is exposed to a light source. The long axis of the gold nanorod scatters red light when the nanorod is in a first position. The short axis of the gold nanorod scatters green light when the nanorod is in a second position. A polarizing filter filters the red and green light to detect the rotational motion by observing alternating red and green lights. A detection DNA stand (50) is coupled between the gold nanorod and the molecular structure. The detection DNA strand hybridizes with a target DNA strand (58) if the target DNA strand matches the detection DNA strand to form a structural link between the molecular structure and gold nanorod.
机译:纳米级运动检测器将金纳米棒( 30 )附着到分子结构( 10 )的旋转臂( 26 )上以引起纳米粒子旋转。分子结构是F1-ATP酶。金纳米棒暴露于光源。当金纳米棒处于第一位置时,金纳米棒的长轴散射红光。当纳米棒处于第二位置时,金纳米棒的短轴会散射绿光。偏光滤镜过滤红光和绿光,通过观察红光和绿光交替来检测旋转运动。检测DNA支架( 50 )连接在金纳米棒和分子结构之间。如果目标DNA链与检测DNA链匹配,则检测DNA链与目标DNA链( 58 )杂交,从而在分子结构和金纳米棒之间形成结构链接。

著录项

  • 公开/公告号US2011212510A1

    专利类型

  • 公开/公告日2011-09-01

    原文格式PDF

  • 申请/专利权人 WAYNE D. FRASCH;LARS CHAPSKY;

    申请/专利号US201113103497

  • 发明设计人 LARS CHAPSKY;WAYNE D. FRASCH;

    申请日2011-05-09

  • 分类号C12M1/34;B82Y35/00;

  • 国家 US

  • 入库时间 2022-08-21 18:13:37

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