A multiple layer microfluidic system and multiple layer microbubble are disclosed. The microfluidic system for producing multiple layer microbubbles includes a first inlet which receives a gas and directs the gas into a central stream, a second inlet which receives an oil and flow focuses the oil around the gas, a third inlet which receives a polymer and lipid solution and flow focuses the polymer and lipid solution around the oil and a fourth inlet which receives a surfactant solution and flow focuses the surfactant solution around the polymer and lipid solution. The multiple layer microbubble includes a gas core, a polymer and lipid shell surrounding the gas core and a surfactant layer surrounding shell.
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