MICRONEEDLE ARRAY CHIP, DEVICE AND PATCH FOR TRANSDERMAL DRUG DELIVERY UTILIZING THE SAME, AND PREPARATION METHOD THEROF

摘要

The invention discloses a microneedle array chip comprising metal microneedles and a substrate, wherein the microneedle consists of a needle head with a tip at its top, a needle bar and a needle seat, and is fixed onto the substrate via the needle seat; and the needle bar of the metal microneedle, having a cylindrical or conical shape, is inclined toward the substrate at a preset angle, and the needle head has a conical shape, or the upper surface of the tip is an oval plane or oval ring plane parallel to the substrate or inclined toward it at a preset acute angle. The metal microneedles in the microneedle array chip of the invention have firm structures to avoid fracture, and have sharp tips to facilitate puncturing. The maximal puncturing depth of the microneedles is easy to adjust and control. The microneedles in the array have good uniformity, and are safe and reliable to use. The hollow microneedles, like conventional syringe needles, have lateral openings, and thus can effectively avoid the blockage of the infusion poles by skin, thereby facilitating rapid diffusion and absorption of drugs, and resulting in significant therapeutic effects.