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Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering
Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering
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机译:通过代谢工程异源生产红霉素和产生新的红霉素衍生物
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摘要
Provided are nucleic acid molecules comprising at least a functional fragment of the capreomycin biosynthetic gene cluster, polypeptides encoded by the cluster and recombinant host cells transformed with any of the nucleic acid molecules disclosed herein. Various methods using any of the vectors or expression cassettes that encode one or more of the gene products of the cluster are provided for heterologous production of capreomycin and capreomycin derivatives.
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