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Use of ADNF III polypeptides for treating mental diseases and disorders, including schizophrenia
Use of ADNF III polypeptides for treating mental diseases and disorders, including schizophrenia
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机译:ADNF III多肽在治疗精神疾病和疾病(包括精神分裂症)中的用途
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摘要
This invention relates to the use of ADNF III polypeptides in the treatment of mental diseases or disorders, including schizophrenia. Embodiments of the invention provide methods for treating mental disorders, including schizophrenia, in a subject by administering a NAP, an 8-amino-acid peptide derived from Activity Dependent Neurotrophic Factor (ADNF III), in an amount sufficient to reduce or eliminate symptoms. The ADNF III polypeptides include polypeptides, analogs, subsequences, and D-amino acid versions (either wholly D-amino acid peptides or mixed D- and L-amino acid peptides), and combinations thereof which contain the active core sites and provide neuroprotective and anti-schizophrenic functions.
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