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Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers
Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers
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机译:合成对映体美西律类似物和新型β-硫代苯氧基和吡啶基醚的方法
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摘要
A practical and efficient procedure for the enantioselective synthesis of mexiletine analogues using 10% of a novel spiroborate ester as chirality transfer agent is presented. A variety of mexiletine analogues were prepared with excellent enantioselectivities (91-97% ee) in good yield from readily available starting materials. The developed methodology was also successfully applied for the synthesis of novel β-amino ethers containing thiophenyl and pyridyl fragments.
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