AN IMPROVED METHOD TO SYNTHESIZE VITAMIN B_(12) COENZYME ANALOGUES CONTAINING 2′-DEOXYNUCLEOSIDE

摘要

A new vitamin B12 coenzyme analogue 2’,5’-dideoxyuridinyicobalamin and two other 2’,5’-dideoxynucleosidecobalamins of adenosyl-and thymidyl-were synthesized by an improved method, It consists in direct tosylation of the nucleoside and followed by reaction with reduced hydroxocobalamin(vitamin B12). All the 2’-deozynucleoside derivatives were characterized by UV-Vis and 1HNMR spectroscopy.