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Hepatocyte-targeting vehicle for delivery of glargine insulin to a mammal
Hepatocyte-targeting vehicle for delivery of glargine insulin to a mammal
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机译:肝细胞靶向载体,可将甘精胰岛素输送至哺乳动物
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摘要
The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free glargine insulin and glargine insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Glargine insulin is present within the complex in at least one form wherein the glargine insulin has a positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.
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