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Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
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机译:芳基甲基化(苄基化)在化学合成过程中保护醇基的化合物和方法
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摘要
A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
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