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Recombinant HIV-1 gp120 immunogen with three different V3 loops from viruses of different clades
Recombinant HIV-1 gp120 immunogen with three different V3 loops from viruses of different clades
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机译:具有来自不同进化枝病毒的三个不同V3环的重组HIV-1 gp120免疫原
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摘要
A novel immunogenic HIV-1 Env, particularly gp120, DNA construct is disclosed in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. Preferably, each replacement V3 loop is a consensus sequence of V3 of a different clade. Such constructs are useful as immunogens as each presents three independent V3 epitopes, so that the immunized subject generates a more broadly reactive neutralizing antibody response than with conventional gp120 or V3 DNA or polypeptide immunogens. Also disclosed are methods of using the DNA construct to immunize a mammal, preferably a human, particularly in a priming regiment in which the DNA immunogen is followed by administration of a V3 fusion protein boosting immunogen.
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