Heterocyclic pyrrolidines Melanocortin Receptor agonists, Pharmaceutical compositions containing them and Use thereof in the treatment of Obesity, Diabetes and erectile dysfunction.

摘要

Claim 1: a compound of the formula (1) wherein: R1 represents h, alkyl or cycloalkyl - 10 represents C1, C3 C6 - 10 - 7, aryl or heteroaryl, a heterocycle, each of which is insustituido or substituted with at least one Substituent selected from the Group C Consists in Halogen, c1-4 alkyl amino, Hydroxy, alkoxy, trifluoromethyl, c1-4,Ciano and oxo; R2 represents phenyl or heteroaryl 6 members, each of whom is insustituido or mono - or alkylated with one or more substituents selected from the group consisting of halogen, Hydroxy, c1-4 alkyl, c1-4 alkoxy, amino and cyano; R3 represents h, alkyl or represents Cycloalkyl or C1 - C3 - 6 or 7,Each of which is insustituido or substituted with one or more substituents selected from the group consisting of halogeno, trifluoromethyl Methyl, Hydroxy and amino; R4 represents cycloalkyl C4 - 7 or a monocyclic heterocycle, each of which is insustituido or mono - or Poly sust Ituido with one or more substituents selected from the group consisting of halogen, Hydroxy,C1-4 alkyl, trifluoromethyl, c1-4 alkoxy and oxo represents phenyl or heteroaryl; or a six member, each of which is insustituido or mono - or di substituted with one or more substituents selected from the group consisting of halogen, Hydroxy, trifluoromethyl, c1-4 alkyl, alkoxy C1-4 alkyl, amino, and R5 represents 6 difluorometilo C1, C3, trifluoromethyl, cycloalkyl - 6Amino alquilamino c1-4 alkyl 4amino C1 -, di -, a monocyclic heteroaryl phenyl or a monocyclic heterocycle where alkyl is insustituido or substituted with at least one Substituent selected from the group consisting of fluoro, Hydroxy, mercapto, c1-4 alkoxy, acetoxy amino, ACET Ilamino, cyano, carbamoilo,Dimethyl carbamoilo and oxo and phenyl or heteroaryl is insustituido or mono - or di substituted with one or more substituents selected from the group consisting of halogeno, trifluoromethyl Methyl, Hydroxy, amino, methoxy and, or a pharmaceutically acceptable Salt or an isomer thereof.