Intra oral dosage form with multiple portions of organoleptic Properties. Formulations

摘要

In the form of a multi part oral internal dose, including at least one drug active agent or health promoting agent, at least a part of which contains an obvious sensory perception component. The use of sensory markers or signals as conceptual aids to the use of dosage forms of objects in such a way that sensory perception (is) sensory (is) helps to identify and distinguish different parts of the object. A method and system for managing active agents, such as nicotine and / or its metabolites, such as Konica, n'oxynicotine, nor nicotine,(S) -nicotine-N-Beta-glucuronide and mixtures thereof, isomers, salts and inclusion complexes, as well as the use and production of said dosage forms. Claim 9: An intra-oral dosage form of multiple portions according to any of the preceding claims, wherein the portions also have different dissolution and different dissolution times. Claim 10: An intra-oral dosage form of multiple portions according to claim 9, wherein at least one portion disintegrates more rapidly than at least another,Each component contains at least one item selected from one component to treat tobacco dependence, an effective pharmaceutical ingredient, a simulated nicotine ingredient, a pH damping ingredient, a pH regulating ingredient, a taste, an obstacle ingredient, a color ingredient, An adhesive, an antiseptic, a cosmetic, a toothbrush, a breath freshener, an oral health promoter and an antitoxic. Item 23: a form of oral endocrine according to item 21Here the nicotine absorption complex is a cyclopentanediol complex, where cyclopentanediol is selected from alpha cyclopentanediol,Beta E andCyclopentanediol derivatives of type ABeta -E and -ciclodextrinas sulfobutil ter tales como por ejemplo beta-ciclodextrina sulfobutil ter ciclodextrinas alquilatadas tales como beta-ciclodextrina metilatada al azar y ciclodextrinas ramificadas tales como glucosil- y maltosil-beta-ciclodextrina Reivindicacion 27 Una forma de dosificacion intra oral de multiples porciones de acuerdo con cualquiera Tc-2559, RJR-2403, ssr180711, GTS-21 and / or citisian. Item 49: an oral multiple dose oral endocrine method, meeting any of the requirements of items 9-27 and 32-47, wherein at least a part of rapid dissociation includes at least one drug active agent selected from the group of amphetamine, dextrometorphan and dibenzylamine, Ambroxol, clorofeniramina, barbidiol, delta-9-tetrahydrocanabinol, clofdianol, and pseudofedrina, at least some of which contain at least one kind of drug active agent selected from menthol, nicotine, diclonina, benzocaina, timol,Methyl salicylate and eukalipto. Item 51: multiple parts of an oral endocrine meet any requirements 9-27 and 32-50, at least one of which is a compressed partOne way and at least part of the slow dissociation has a matrix, which is a hard Caramel glass. Requirement No. 55: including nicotine and / or its metabolites in accordance with requirements 1-27 and 32-51such as for example cotinine, N 'nicotine oxide, nornicotine, (S) -nicotine-N-beta-glucuronide and mixtures thereof, isomers, salts and complexes, in any form, to be used in therapy, where the therapy is the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerative colitis and weight control after quitting smoking.