Isoxazolicos resorcinol Derivatives, Pharmaceutical compositions containing Intermediates, Synthesis process, The Synthesis and use of same in Neurodegenerative Disorders and as antitumor agents.

摘要

This request is directed at alternative m-phenol derivatives that inhibit Hsp90 heat shock protein activity. Therefore, the compound in the application can be used for the treatment of diffuse diseases such as cancer and neurodegenerative diseases. The application also provides the preparation process of these compounds, the pharmaceutical ingredients containing these compounds, the method for treating diseases and the pharmaceutical ingredients containing these compounds. Requirement 1: the properties of a compound, because it has formula (1), where Z is - CH = ch,- (CH2) p, where p is 0, 1, 2 or 3, NH, O, S, S = O, SO2 or C = O; R is an optionally substituted linear or branched C1-7 alkyl, C2-7 alkenyl or C2-7 alkynyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, phenyl, naphthyl, 5- or 6-membered heteroaryl, saturated or partially heterocyclic ring saturated comprising one or more oxygen, sulfur or nitrogen atoms, or is a CONHR2, CH2NHR2, NHCOR2 or NHCONHR2 group where R2 is an optionally substituted linear or branched C1-7 alkyl, C2-7 alkenyl or C2-7 alkynyl group, C3-7 cycloalkyl, C4-7 cycloalkenyl, phenyl, naphthyl, 5- or 6-membered heteroaryl,A saturated or partially saturated heterocycle consisting of one or more oxygen, sulfur, or nitrogen atoms; X is ch, N, NH, or O; w e is an independent ch, N, NH, or s; R1 is a group of NH2, nhconhr2, nhcor2, nso2r2, or conhr2, R2 is defined above; a ring containing x, Y and W, as defined above, are a heteromorphic group, or a medically acceptable salt.