Derivatives of 3 - amino - 4 - phenyl - 5,6 dihydro - 2H - (1,4) oxazine

摘要

They have the activity of inhibiting bacteria and / or bacteria, their reproduction, drug synthesis containing these substances, and their use as therapeutic active substances. The active compound of the invention can be used for treatment and / or prevention, such as Alzheimer's disease and type 2 diabetes. Item 1: a formula compound (1)wherein X is O or S, R1 is selected from the group consisting of i) lower alkyl, ii) lower alkyl substituted by 1-5 substituents individually selected from cycloalkyl, halogen, halogen-lower alkoxy and lower alkoxy and iii) cycloalkyl , R2 is selected from the group consisting of i) H, ii) lower alkyl, iii) lower alkyl substituted by 1-5 substituents individually selected from cycloalkyl, halogen, halogen-lower alkoxy, heterocyclyl and lower alkoxy, iv) aryl, v ) aryl substituted by 1-4 substituents individually selected from cyano, cyano-lower alkyl, halogen, halogen-lower alkoxy, halogen-lower alkyl, heteroaryl, lower alkoxy,(lower alkoxy)-lower alkyl and lower alkyl, vi) cycloalkyl, vii) cycloalkyl substituted by 1-4 substituents individually selected from cyano, cyano-lower alkyl, halogen, halogen-lower alkoxy, halogen-lower alkyl, lower alkoxy, ( lower alkoxy)-lower alkyl and lower alkyl, viii) heteroaryl, ix) heteroaryl substituted by 1-4 substituents individually selected from aryl, cyano, cyano-lower alkyl, halogen, halogen-lower alkoxy, halogen-lower alkyl, cycloalkyl-alkoxy lower, (lower alkenyl) -alkoxy lower, aryl-lower alkoxy, heteroaryl, heterocyclyl, lower alkoxy,1.1.1.1 (low oxygen) - non cyclohexane was replaced by 1-4 substitutes, including: aminobenzene, cyanogen, cyano-below, halogenated, halo-below, halo-below, low oxygen (low oxygen), alcox (low oxygen) - low layer and tar, R3 is elected in the group consisting of (I) hydrogen halide and (II) lower tar, R4 is elected in the group consisting of (I) H and (II) lower tar, R5 is elected in the group consisting of (I) H and (II) lower tar, R6 is elected in the group consisting of (I) H and (II) lower tar.R7 was selected from a group consisting of (I) h, (II) arilo and (III) lower tar and (n) 0, 1 or 2 or salts acceptable to the drug.