vaccine administration methods, feline caliciviroses, and treatments to immunize animals against feline paraoviruses and feline herpes viruses

摘要

VACCINE ADMINISTRATION METHODS, FELINE CALICIVIROSIS, AND TREATMENTS TO IMMUNIZE ANIMALS AGAINST FELINE PARAOVIRUSES AND FELINE VIRUS HERPES. The present invention relates to a vaccine to immunize cats against feline viruses. The present invention also relates to a nucleic acid clone that encodes the isolated feline calicivirus capsid protein. The present invention also relates to a live or dead vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the isolated feline calicivirus capsid protein, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the isolated feline calicivirus capsid protein. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and to assays for diagnosing cats infected with feline calicivirus. Also described is a method for immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of the first and second FCV vaccine. The first vaccine is administered orally or parenterally (for example, subcutaneously, intramuscularly, and others). The second vaccine is administered orally or oronasally N days after the administration of the first vaccine, where N is an integer from 3 to 120 inclusive. A third vaccine administration can also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccines, and in particular cats against both FPV or Feline Parvovirus which was also called Panleukopenia or FPL and against another disease, FHV or Feline HERPES VìRUS which was also called Virus Feline Rhinotracheitis.