Domu00ecnio antibody recombinant nucleic acid molecule isolated, pharmaceutical composition, and methods for detecting TNF alpha human in a sample and to treat a disorder distinguished by the activity of the TNF alpha human in a human indivu00ecduo

摘要

Domu00ecnio antibody recombinant nucleic acid molecule isolated, pharmaceutical composition, and methods for detecting TNF alpha human in a sample and to treat a disorder distinguished by the activity of TNF alpha human in a human indivu00ecduo the present invention provides a antic Orpo recombinant domain (DAB) that binds to the TNF - 244 human.The DAB comprising the field variable heavy chain or light immunoglobulin, which referred to the field variable comprises at least a region determinant of complementarity (CDR) having a sequ00fau00e9ncia derived from a primate of the new world, in which the CDR is selected from the group consisti The world yaatklqs (SEQ ID No: 1), yeasslqs (SEQ ID No: 2), yeasklqs (SEQ ID No: 3) and ysasnlet (SEQ ID No: 4).The recombinant domain antibody is used to detect TNF - 244 human in a sample, and to treat a disorder characterised by the activity of the TNF - 244 human.