Calpastatin markers for fertility and longevity.

摘要

Markers for calpastatin ferti time and longevity. The present invention relates to compositions and methods based on new genetic markers calpastatin (CAST), such as mutations in exon 3 without sense that result in substitutions g48d or p52l (nm174003.2: c.271g . And 283C t) A replacement g / T in intron 3 (- afc02060381. 1 g.21 1og t) and a repetition GAAA in intron 8 (- afc0206038 1.1: G. 6700 [(GAAA) 4] + [(GAAA) 5]. Particular aspects provide new markers for fertility (e.g., pregnancy rate of race, DPR) and longevity (for example, productive life, PL) in, for example, dairy cattle.Additional aspects provide novel methods including selection assisted by marker to improve fertility and / or longevity in dairy cattle.Therefore, in particular achievements, a combination of genetic selection based on one or more of the new markers cast, and high potential of PTA for milk production traits, provides improved reproductive traits in association with milk production traits of high C Ontinuada.Additional aspects desgeram an area previously not recognized in XL gene human cast, and thus provides the use of mutants / variants of field cast XL as markers for fertility and longevity of life.