Similar deamidas heteroarilicas as antagonists of P2X7

摘要

Or a pharmaceutically acceptable Salt thereof, wherein: T, u and V are selected independently between Cr3, CRA and N, such that (i) exactly one T, u and V is CRA; and (ii) IF x is CH2 and phenyl, and u and V are both carbons replaced then t is n; W - C (= o) - NR4.- nr4c (= o) - or NR4 NR4 - C (= o) - X is absent or is alquileno C1 - C6 is replaced with 0 to 4 substituents chosen independently between: (i) c1-c4 alkyl,(cycloalkyl alkyl C0 - C1 - C2 and C8) fenilalquilo C0 C2; (ii) substituents are taken together to form a ring heterocicloalquilo cycloalkyl or 3 to 7 members; and (iii) substituents are taken together to form a heterocicloalquilo R4 4 - to 7 - is cicloalqu members; and ILO - C16 heterocicloalquilo C3, 4 - 16 - member6 - to 16 - aryl or heteroaryl - member of 5 to 16 members, each of whom is replaced with 0 to 6 chosen independently between hydroxy substituents, halogen, Nitro, cyano, amino, Oxo, aminocarbonilo, aminosulfonilo alquiloc1, COOH, - C2 - C6, alquenilo alquinilo C2 - C6 c6a, haloalqu ILO - C6 C1 - C6, hidroxialquiloc1, aminoalquilo C1 - C6, alcoxic1 - haloalcoxic1 - C6 C6C2 - C6 alkyl ether, alcanoilo C1 - C6, alquilsulfoniloc1 - (C3 - C7 C6, cycloalkyl) alkyl C0 C4 -, mono - or di - (alquilc1 - C6) alcanoilamino C1 - C6 amino, mono - or di - (alquilc1 - C6) aminocarbonilo, mono or di (alquilc1 - C6) aminosulfonilo and (alquilc1 - C6) sulfonylamino; Z1 and Z3 N or CR2 are independently; Z2 is n, CR2 or CRA; each R2 and R3 are each independently selected from Hydrogen, halogen, a cyano,Aminocarbonilo, amino, Nitro, aminosulfonilo, COOH, c1-c6 alkyl, alquenilo C2 - C6, alquinilo C2 - C6, haloalquilo C1 - C6, hidroxialquilo c1-c6 alkoxy, aminoalquilo C1 - C6 C1 - C6, haloalcoxi C1 - C6, alcanoilo C1 - C2 - C6 C6 alkyl ether, (cicloalquilc3 - C7) C0 C4 alkyl -, mono - or di - (alquilc1 - C6 amino alkyd) Ilsulfonilo C1 - C6, alcanoilamino C1 - C6, mono - or di - (alquilc1 - C6) aminocarbonilo,Mono - or di - (alquilc1 - aminosulfonilo (C6) and alquilc1 sulfonylamino - C6) each independently; R4 is Hydrogen, alkyl (C1 - C6, C8 alkyl - cicloalquilc3) C0 C2...