Compositions comprising microparticles of a Copolymer of lactic acid and Glycolic Acid (PLGA) with an active substance in the form of a Salt insoluble peptide

摘要

A pharmaceutical composition made of microparticles for the slow release of an active substance, at least during a period covering the 6th month after the injection of the composition, the composition comprises a group of microparticles made of a PLGA type copolymer, which incorporates an active substance in the form of a water insoluble peptide sa the copolymer further comprises at least 75% lactic acid and an inherent viscosity between 0.1 and 0.9 dl / g, measured in chloroform at 25 ° C, and at a polymer concentration of 0.5 g / dL; The microparticles also have a defined size distribution as follows: - D (v,D (V, 0.5) is 30 to 70 microns and D (V, 0.9) is 50 to 110 microns. 1. - the drug composition of the microparticle, whose active substance is released slowly for at least six months after injection, including a group of microparticles made of PLGA type copolymers containing active substance In the form of water-insoluble peptides; the copolymer also contains at least 75% lactic acid and an intrinsic viscosity of 0.1 to 0.9 DL / g,seg n se mide en cloroformo a 25 C y una concentraci n de pol mero de 0 5 g 2FdL dichas micropart culas adem s tienen una distribuci n de grano que se define de la siguiente manera - D (v 0 1) est entre 10 y