Population of microparticles comprising a corticosteroid Class B incorporated in a Matrix comprising a Copolymer of lactic acid and Glycolic AcidWhere this corticosteroid includes 22 to 28 of the microparticles for controlled release; Preparation; formulation; and Manufacturing method.

摘要

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous Cortisol production.