Solid forms of (S) - ethyl - 2 - amino - 4 - (4 - (2 - amino - 6 ((R) - 1 - (4 - (2 - chlorine - 3 - methyl - 1 - 1H pyrazole - yl) - phenyl) - 2,2,2,2 trifluoroetoxi) - pyrimidine - il - 4) phenyl) propanoate and Methods of use

摘要

1. Solid (s) - ethyl-2-amino-3 - (4 - (2-amino-6 - ((R) - 1 - (4-chloro-2 - (3-methyl-1h-pirazol-1-il) phenyl) - 2,2-trifluoroiodin XI) pirimidin-4-il) phenyl of propane and its salts. 1 - (1 - (1 -) (1 -) (1-chloro - (1-pirazol-1-ii) phenyl-2, 2, 2-trifluoroetoxi) pirimidin-4-il) phenylpropane crystal. 3. - No. 2 industrial compound;having a melting point of 104 ° C. 4. The compound of claim 2, having a powder X-ray diffraction pattern, with peaks at one or more than about 10.7, 12.2, 12.8, 17.7 and / or 22.0 degrees 2 ?. 5.- The compound of claim 2, which has a powder X-ray diffraction pattern that is substantially the same as that shown in Figure 1.6.- A crystalline salt of (S) -ethyl 2-amino- 3- (4- (2-amino-6 - ((R) -1- (4-chloro-2- (3-methyl-1H-pyrazol-1-yl) phenyl) -2,2,2-trifluoroethoxy) pyrimidin-4-yl) phenyl) propanoate. 7.- The crystalline salt of claim 6, which is a hippurate salt. 8.- The crystalline salt of claim 7,This is the crystal salt of claim 7, an X-ray powder diffraction device consisting of one or more peaks, about 8.2, 9.5, 12.6, 16.9, 21.8, 22.0, 22.7, 24.3 or 29.1 degrees.