Derivatives of 1,2,3,4 - tetrahidropirrolo 1,2 pyrazine carboxamidas 2,3,4,5 and 6 - - - tetrahidropirrol 1,2 1,4 - diazepina - 7 - carboxamidas Preparation and its application in Therapeutics

摘要

The invention refers to derivatives (I) of 1,2,3,4-tetrahydropyridine - [1,2-a] - pyridine-6-carbohydrates and 2,3,4,5-tetrahydropyridine [1,2-a] [1,4] - diazo-7-carbohydrates,R1 represents a hydrogen atom, an asphalt group (C1-C10),Bicycle (C3-C7),(CH2) n-alquenilo (C1-C6)(CH2) n-bitumen (C1-C6),1. Asphalt (C1-C6) - z-asphalt (C1-C6),Z represents the heteroatom selected from O, N and S (o) m or R1, represents a coor, s (o) Sr, arilo or aralquilo group, R2 represents one or more groups selected from hydrogen, halogen, tar group (C1-C6),Bicycle (C3-C7),alquenilo (C1-C6)1. Asphalt (C1-C6),1. Asphalt (C1-C6) - z-asphalt (C1-C6),Z represents a heteroatom selected between O, N and S (or) m, or R2 represents a halide (C1-C6) group,1. Halogenated alcoxi (C1-C6),Hydroxyl, oxygen (C1-C6),nitro ciano amino un grupo NR7R8 COOR C (O) NR7R8 O-C (O) alquilo (C1-C6)S (o) m-nr7r8, an arilo group; R3, a trifluorometric group; R4 and R5, respectively, represent a hydrogen atom or R4 and R5, which form a saturated cycle with carbon atoms, consisting of 3 to 6 carbon atoms, optionally containing 0 to 1 heteromorphic atom selected from O, n or s; R6 represents a group selected from the hydrogen atom, halogen atom and tar group (C1-C6),Bicycle (C3-C7),1. Nitro, amino, UN group nr7r8, coor, UN group arilo, UN group NR7 (SO2) R8 o C (o) nr7r8; W represents a sub A or C (o);M represents an integer from 0 to 2, n represents an integer from 1 to 6, and P represents an integer from 2 to 3. 1. Treatment preparation and application.