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Control of androgen receptor-dependent gene expression by inhibiting the amine oxidase activity of lysine-specific demethylase (LSD1)
Control of androgen receptor-dependent gene expression by inhibiting the amine oxidase activity of lysine-specific demethylase (LSD1)
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机译:通过抑制赖氨酸特异性脱甲基酶(LSD1)的胺氧化酶活性来控制雄激素受体依赖性基因表达
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摘要
The invention relates to the use of at least one amine oxidase inhibitor for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal and to pharmaceutical compositions for controlling the androgen receptor-dependent gene expression, comprising an effective dose of at least one amine oxidase inhibitor suitable for modulating the activity of the lysine-specific demethylase (LSD1) in a mammal. The invention also relates to assay systems allowing to test LSD1 inhibitors for their ability to inhibit LSD1 function.
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