PHARMACEUTICAL PRODUCT COMPRISING (I) EXTRUDED PARTICLES CONTAINING AN OPIOID ANTAGONIST; (2) PARTICLES CONTAINING AN OPIOID AGONIST; AND (3) EACH OF THE TWO MATRICES IN WHICH THE PARTICLES ARE DISPERSED AND THE LAYER BETWEEN THEM CONSIST OF DIFFERENT HYDROPHOBIC MATERIALS

摘要

Disclosed in certain embodiments is a dosage form comprising a plurality of extruded particles comprising an adverse agent or antagonist and a layer disposed about the particles.