COMPOSITION COMPRISING AN ISOLATED AGONISTIC ANTIBODY WHICH SPECIFICALLY CROSS REACTS WITH DIFFERENT APO - 2L RECEPTORS FOR USE IN INDUCING APOPTOSIS IN MAMMALIAN CANCER CELLS

摘要

A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.