NON-NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR THE PROPHYLAXIS OR TREATMENT OF HIV-1 INFECTIONS

摘要

Compounds of the formula Z: where; A is CH or N; R1 is a substituent to a carbon atom in the ring containing A selected from S(O)pRa, where Ra is C1-C4 alkyl, ORx, NRxRx, NHNRxRx, NHNHC(O)ORx, NRxOH; C(O)Rb, where Rb is CT-C4-alkyl, ORx, NRxRx, NHNRxRx, NHC1-C3-alkyl-C(O)Orx NRxRc, where Rc is H, C1-C4 alkyl, NRxRx; C(=0)Rd, CN, S(O)pRx, where Rd is Rd is C1-C4-alkyl, ORx, NRxRx C1-C3-alkyl-OC1-C3-alkylC(O)ORx, C1-C3-alkyl-COORx; C1-C3alkyl-OH or C1-C4 alkyl ethers or esters thereof (OC1-C3alkyl)q-ORx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, S(O), or CH2, where r is 0, 1 or 2; R3-R7 are substituents as defined in the specification; X is (CR8R8)n-D-(CR8R8)m-; D is a bond, NR9, -0-, S, S(=0)- or S(=0)2-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals.