INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-9 (IL-9) CHIMERIC MUTEIN RECEPTOR ANTAGONISTS, COMPOSITIONS COMPRISING THEM, POLYNUCLEOTIDE ENCODING THEM, METHODS OF THEIR PRODUCTION AND USES THEREOF

摘要

Chimeric polypeptide antagonists that include an interleukin-4 (IL-4) mutein linked to an interleukin-9 (IL-9) mutein are provided, as are polynucleotides encoding the IL-4 and IL-9 chimeric mutein antagonists. Also provided are methods of using the chimeric mutein antagonists and encoding polypeptides to reduce or inhibit the responsiveness of a cell to a cytokine such as IL-4, IL-9 and/or interleukin-13. Methods using the compositions to treat disorders such as pulmonary disorders (e.g., asthma) also are provided.