METHODS FOR DETERMINING EFFECTIVENESS OF AN ANTI-INFLAMMATORY TREATMENT AND FOR SELECTING A SUBJECT TO RECEIVE SUCH TREATMENT

摘要

Inflammatory state in a subject is assayed by determining the level of expression of A3 adenosine receptor (A3AR) in white blood cells (WBC), e.g. circulating WBCs, from the subject. A high level of expression of A3AR is indicative of an inflammatory state in the subject. This assay can be used for determining the severity of inflammation in a subject and monitoring the efficacy of anti-inflammatory treatment. Also, the level of expression may be used for selecting patients to receive an anti-inflammatory treatment that comprises an A3AR agonist.