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PROCESS FOR PREPARING AN IMMUNOGENIC COMPOSITION COMPRISING THE STEPS OF COMBINING A VIRAL SURFACE ANTIGEN COMPONENT THAT INCLUDES A SURFACTANT AND A FATTY ADJUVANT COMPONENT
PROCESS FOR PREPARING AN IMMUNOGENIC COMPOSITION COMPRISING THE STEPS OF COMBINING A VIRAL SURFACE ANTIGEN COMPONENT THAT INCLUDES A SURFACTANT AND A FATTY ADJUVANT COMPONENT
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机译:制备包含组合表面活性剂和脂肪佐剂组分的病毒表面抗原组分的步骤的免疫原性组合物的方法
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摘要
Inclusion of fatty adjuvants in vaccine compositions can cause difficulties with certain antigenic components, particularly with antigens that include a surfactant component. A method for preparing an immunogenic composition comprising an antigen and a fatty adjuvant involves purification of the antigen substantially in the absence of surfactant. Where surfactants cannot be avoided, the following are combined: (i) an antigen component that includes a surfactant and (ii) a fatty adjuvant component, to give a composition in which the weight ratio of said fatty adjuvant to said surfactant is less than 1000:1.
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