KNOCK-OUT MOUSE OF THE MO-1 GENE-A GENE ASSOCIATED WITH MORBID OBESITY

摘要

A conditional knock-out non-human animal is disclosed. Wherein some cells of the non-human animal but not all the cells comprise a disrupted MO-1 nucleic acid sequence, wherein the disruption results in an inability of the non-human animal to produce detectable levels of the MO-1 protein, as assayed by Southern blot analysis.