首页>
外国专利>
PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE IN VIVO GENE SILENCING IN A MAMMALIAN CELL
PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE IN VIVO GENE SILENCING IN A MAMMALIAN CELL
展开▼
机译:哺乳动物细胞中体内基因沉默的小干扰RNA的产生
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs (siRNAs) that selectively silence targeted genes (by cleaning specific mRNAs) using the cell's own RNA interference (RNAi) pathway. By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.
展开▼