首页> 外国专利> 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO1,2-BPYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF

2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO1,2-BPYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF

机译:2-烷基-6-环戊基-3-(吡喃-4-基)咪唑并[1,2-B]吡嗪衍生物,其制备及在治疗中的应用

摘要

The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
机译:本发明涉及通式(I)的2-烷基-6-环氨基-3-(吡啶-4-基)咪唑并[1,2-b]哒嗪衍生物,其中:R2是C1-6-烷基,C3 .7-环烷基,C3-7-环烷基-C1-4-烷基,C1-4-烷氧基-CM-烷基,C3-7-环烷氧基-C1-4-烷基> C3.7-环烷基-C1-4-烷氧基-C 1-4-烷基,羟基-C 1-6-烷基,C 1-4-氟烷基; R3是氢原子或选自卤素原子和C1-3烷基,-NR4R5,羟基或C1-4烷氧基的取代基; A为任选地被一个或两个Ra基取代的C-1-7亚烷基; B为任选地被一个或两个Rb基团取代的C-1-7亚烷基; L为任选被Rc或Rd基团取代的氮原子或被Re1和Rd基团或两个Re2基团取代的碳原子;或Rd是选自氢原子或C 1-6-烷基,C 3-7-环烷基,C 3-7-环烷基-C 1-6-烷基,C 1-6-烷硫基-C 1-6-烷基,C 1的基团。 -6-烷氧基-C 1-6-烷基,C 1-6-氟烷基,羟基-C 1-6-烷基; Rf是C 1-6-烷基,C 3-7-环烷基,C 3-7-环烷基-C 1-6-烷基,C 1-6-烷氧基-C 1-6-烷基,C 3-7-环烷氧基-C 1-4-烷基。 ,C3-7-环烷基-C1-4-烷氧基-C1-4-烷基,羟基-C1-6-烷基,C1-6-氟代烷基或苄基。本发明还涉及其制备方法及其治疗用途。

著录项

  • 公开/公告号IL211141A

    专利类型

  • 公开/公告日2011-04-28

    原文格式PDF

  • 申请/专利权人 SANOFI;

    申请/专利号IL211141

  • 发明设计人

    申请日2011-02-09

  • 分类号C07Dnull/null;

  • 国家 IL

  • 入库时间 2022-08-21 18:06:04

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