NOVEL AMINE SALTS OF TENOFOVIR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF IN PRODUCTION OF TENOFOVIR DIOPROXIL

摘要

Disclosed herein are novel amine salts of tenofovir and a process for producing the same. In addition, provided is a crystalline form of chloromethyl isopropyl carbonate solvate of tenofovir disoproxil. Furthermore, a process for producing tenofovir disoproxil and its pharmaceutic ally acceptable salt in high purity and yield employing the novel amine salt of tenofovir and tenofovir CMIC solvate is disclosed.