SYNTHESIS OF NOVEL 3-SUBSTITUTED (7-IMINO-2-THIOXO-3,7-DIHYDRO-2H-THIAZOLO 4,5-DPYRIMIDIN-6-YL)-UREA AND FURAN-2-CARBOXYLIC ACID (7-IMINO-2-THIOXO-3,7-DIHYDRO-2H-THIAZOLO 4,5-D PYRIMIDIN-6-YL)-AMIDE AS POTENTIAL ADENOSINE A2A RECEPTOR ANTAGONISTS

摘要

The present invention relates to novel 3-substituted (7-imino-2-thioxo-3, 7-dihydro-2H-thiazolo [4,5-d] pyrimidin-6-yl of general formula 1 wherein R is selected from a group consisting of hydrogen, alkyl (having carbon no up to 10 etc.), cycloalkyl, aromatic, substituted aromatics (halogen, OH, COOH, OCH3, alkyl, etc), pyridyl, piperidine, piprazine, morphine. R1 is selected from a group consisting of NH2, NHR, N(R) 2(wherein R could be aliphatic or olefinic group up to 10 carbon), hetrocycles such as furan, thiophene, pyrole, prydyl, piprazine, morphine and R2 is O and S separately. Particularly the present invention relates to (7-Imino-3-substituated -2-thioxo-3,7-dihydro-2H-thiazolo[4,5-d]pyrimidin-6-yl)-urea(15-21) and Furan-2-carboxylic acid (7-imino-3-substituted -2-thioxo-3,7-dihydro-2H-thiazolo[4,5-d]pyrimidin-6-yl)-amide. The compounds of present invention are useful in the treatment of central nervous disorders including, Parkinson disease, Huntington"s disease, attention disorder, cognition, Alzheimer disease, depression and hypertension.